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KMID : 1040620160220030390
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Clinical and Molecular Hepatology
2016 Volume.22 No. 3 p.390 ~ p.395
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Regression of esophageal varices and splenomegaly in two patients with hepatitis-C-related liver cirrhosis after interferon and ribavirin combination therapy
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Lee Soon-Jae
Cho Yoo-Kyung
Na Soo-Young
Choi Eun-Kwang
Boo Sun-Jin
Jeong Seung-Uk
Song Hyung-Joo
Kim Heung-Up
Kim Bong-Soo
Song Byung-Cheol
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Abstract
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Some recent studies have found regression of liver cirrhosis after antiviral therapy in patients with hepatitis C virus (HCV)-related liver cirrhosis, but there have been no reports of complete regression of esophageal varices after interferon/peg-interferon and ribavirin combination therapy. We describe two cases of complete regression of esophageal varices and splenomegaly after interferon-alpha and ribavirin combination therapy in patients with HCV-related liver cirrhosis. Esophageal varices and splenomegaly regressed after 3 and 8 years of sustained virologic responses in cases 1 and 2, respectively. To our knowledge, this is the first study demonstrating that complications of liver cirrhosis, such as esophageal varices and splenomegaly, can regress after antiviral therapy in patients with HCV-related liver cirrhosis.
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KEYWORD
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Esophageal varices, Splenomegaly, Regression, Hepatitis C, Liver cirrhosis, Interferon, Ribavirin
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